Dysfunction of the CaV2.1 calcium channel in cerebellar ataxias
نویسندگان
چکیده
منابع مشابه
Dysfunction of the CaV2.1 calcium channel in cerebellar ataxias
Mutations in the CACNA1A gene are associated with episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6). CACNA1A encodes the α-subunit of the P/Q-type calcium channel or Ca(V)2.1, which is highly enriched in the cerebellum. It is one of the main channels linked to synaptic transmission throughout the human central nervous system. Here, we compare recent advances in the understan...
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ژورنال
عنوان ژورنال: F1000 Biology Reports
سال: 2010
ISSN: 1757-594X
DOI: 10.3410/b2-4